Structure Antimutagenicity Relationship of Anthraquinones
نویسندگان
چکیده
Naturally occurring anti-mutagenic principles present in plants, human diet and other sources have protective effects against mutagens. Anthraquinones (AQs) considered one of the major plant phenolic pigments that contain many members, have evidenced the capability for inhibiting the mutagenicity toward Salmonella typhimurium of a number of mutagens. Not only genotoxicity/carcinogenesis is caused by mutagens but also the inception and pathogenesis of several chronic degenerative diseases. The present review attempts to furnish a brief overview on structure-antimutagenicity relationships of natural and synthetic anthraquinones.
منابع مشابه
Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes
Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, an...
متن کاملCalcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus
Staphylococcal biofilms are problematic and play a critical role in the persistence of chronic infections because of their abilities to tolerate antimicrobial agents. Thus, the inhibitions of biofilm formation and/or toxin production are viewed as alternative means of controlling Staphylococcus aureus infections. Here, the antibiofilm activities of 560 purified phytochemicals were examined. Ali...
متن کاملAnthraquinones from the bark of Senna macranthera.
2-acetyl physcion (2-acetyl-1,8-dihydroxy-6-methoxy-3-methyl-9,10-anthraquinone, 2), a rare anthraquinone, was isolated from Senna macranthera var. nervosa (Vogel) H.S. Irwin & Barneby (Fabaceae). The chemical structure was elucidated and all (1)H and (13)C NMR chemical shifts were assigned by NMR one- ((1)HNMR, {(1)H}-(13)CNMR, and APT-(13)CNMR) and two (COSY, NOESY, HMQC and HMBC) dimensional...
متن کاملBioassay-Guided Isolated Compounds from Morinda officinalis Inhibit Alzheimer's Disease Pathologies.
Due to the side effects of synthetic drugs, the therapeutic potential of natural products for Alzheimer's disease (AD) has gained interest. Morinda officinalis has demonstrated inhibitory effects on geriatric diseases, such as bone loss and osteoporosis. However, although AD is a geriatric disease, M. officinalis has not been evaluated in an AD bioassay. Therefore, M. officinalis extracts and f...
متن کاملUV/Visible spectra of a series of natural and synthesised anthraquinones: experimental and quantum chemical approaches
Root decoctions of anthraquinone-containing plants are often taken as postpartum tonic and aphrodisiac. Anthraquinones are known for their diverse biological activities, especially antioxidant and anticancer. A series of 35 anthraquinones was generated by isolation from Rubiaceae plants and synthesis. Their UV/vis spectrum depends on the nature and relative positions of auxochromic substituents...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016